The accumulation of pseudoexfoliative material can alter both static and dynamic pupillary characteristics, according to investigators. Additionally, their study found a reduced amplitude of pupil contraction is associated progression from pseudoexfoliation syndrome (PES) to pseudoexfoliative glaucoma (PEG). 

The team looked at 40 patients with PES, another 30 with PEG and 43 control subjects. They took static pupillometry measurements such as scotopic pupil diameter, mesopic pupil diameter, low photopic pupil diameter and high photopic pupil diameter as well as dynamic pupillometry measurements that included resting diameter, amplitude of pupil contraction, latency of pupil contraction, duration of pupil contraction, velocity of pupil contraction, latency of pupil dilation, duration of pupil dilation and velocity of pupil dilation. These measurements were compared between the groups.

The research shows that scotopic, mesopic and low photopic pupil diameter values are significantly lower in patients with PES and PEG compared with controls and that the parameters between patients with PES and patients PEG were similar. However, the amplitude of pupil contraction values of patients with PEG was lower than both patients with PES and controls. The PES patients had significantly lower amplitude of pupil contraction values compared with controls, and the velocity of pupil contraction was higher in control subjects.