Reticular pseudodrusen is a finding of morphological changes to the retina associated with various conditions, such as AMD, choroidal neovascularization and geographic atrophy.¹ But uncovering that finding hasn’t always been easy. However, with the development of retinal multimodal imaging, researchers are finding a higher incidence of reticular pseudodrusen than in previous studies that used fundus color images.²

French researchers looked at data from 472 eligible eyes. They identified an annual reticular pseudodrusen incidence per participant of 2.9% and an estimated 13.5% five-year incidence.² Age, choroidal thinning and genetic background were all associated with incident reticular pseudodrusen, whereas lipophilic statin therapy was associated with a lower risk.²

After a multivariable analysis, the team identified four risk factors: subfoveal choroidal thinning and those carrying minor allelic variants for ARMS2, CFH or LIPC.²