Researchers recently discovered that non‐invasive multicolor imaging can detect clinical features of central serous chorioretinopathy (CSCR) so well that it may one day replace fluorescein angiography and color fundus photography as the retinal imaging modality of choice.

A retrospective study evaluated 63 consecutive eyes with CSCR (both acute and chronic) using color fundus photography, OCT, multicolor imaging, fluorescein and indocyanine green angiography and near-infrared and blue wavelength autofluorescence. The team computed sensitivity and specificity values of the clinical features for each.

Upon comparing multicolor imaging with fluorescein angiography, the investigators found the new imaging modality was more effective in identifying the extent of subretinal fluid (78% vs. 13%) but equally capable of identifying pigment epithelium detachment (100% vs. 100%) and retinal pigment epithelial changes (100% vs. 100%). They identified focal leaks in 84% and 97% of eyes using multicolor imaging and fluorescein angiography, respectively.

They add that multicolor imaging was more sensitive in identifying focal retinal pigment epithelial leaks compared with near-infrared autofluorescence (84% vs. 34%) and blue wavelength autofluorescence (84% vs. 18%) imaging.