Findings from a study in Paris suggest that patients with unilateral central serous chorioretinopathy (CSC) who present with specific findings on multimodal imaging should be followed for possible serous retinal detachment (SRD).

Researchers retrospectively assessed 68 patients with unilateral CSC clinical data, baseline late-phase indocyanine green angiography (ICGA) and spectral-domain OCT macular cube for both eyes at baseline and over three months. The study reviewed subsequent OCT images of eyes to detect SRD development during follow-up.

The team found SRD in 19% of eyes during a mean follow-up of 25.8 months. The most significant factor to predict the incidence of CSC was hyperfluorescent plaques on midphase ICGA. The team also found hypofluorescent foci on late-phase ICGA, retinal pigment epithelium changes on fundus autofluorescence and fluorescein angiography abnormalities were associated with SRD occurrence.  

The study concluded that its findings could help to identify patients who could benefit from closer follow-up and screening.